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Testosterone from NuLife Solutions - Features: Testosterone HGH Therapy Benefits, Testosterone Therapy Benefits, Men's Hormone Programs, Women's Hormone Programs, Compounding, Health

TESTOSTERONE

Q: I am 43 years old and was recently diagnosed with a low level of testosterone. Prior to diagnosis I was pretty fatigued as a result of low muscle mass. Last week my doctor started me on daily testosterone and I can already tell that it is working because I am having morning erections once again! This is great! My question is, If I have worked out in the last few years with this low testosterone level, and not seen any results, i.e. mass and definition, when do you think I can expect to feel and look like the old me with a more defined physique?

A: Assuming your physician has you on a replacement regimen that keeps you within physiological limits for a male in your age group, the time to achieve effect will be 3-6 months or longer depending on your workout ethic, and diet and hydration. P.S. Don't forget to have your PSA (Prostate Specific Antigen) level drawn yearly.

Androgen Deficiency & Testosterone

Q: I suffer from easy fatigability, lack of concentration, weak memory, chronic fatigue and frequent dizziness. I am told that those are the symptoms of Androgen-deficiency.
I had a severe illness during my childhood, and as a result I stopped sexual development. I once used testosterone tablets when I was 21 years old to help me develop secondary male sex characteristics such as underarm hair, chest hair and a beard. I am now 36 years old and the situation seem to have worsened as time goes on especially tiredness and dizziness. Is there any medication to cure this?

A: Are you taking testosterone now? Although you are young, it sounds as if your childhood illness left you with a deficiency in testosterone that is affecting the quality of your life. Your testosterone levels should be tested now and at least yearly thereafter. In addition, if you desire to have a family, and you are not on supplemental testosterone yet, have your doctor also get a Luteinizing Hormone (LH) level, if fertility is desired since there are other hormones that may be indicated such as B-HCG that will preserve fertility. I would also recommend that you as for yearly bone density tests as men can also get osteoporosis. Find a good endocrinologist!

What is Testosterone?

Testosterone is the primary sex hormone in males and is produced by the Leydig cells of the testes. The Leydig cells produce testosterone in response to another hormone called Lutinizing Hormone (LH), which is made by the pituitary gland. Testosterone travels through the body via the bloodstream, and primarily binds to receptors on target tissues such as the genitals and the brain.

Testosterone starts to decline because of aging of the Leydig cells in the testicles and may be made worse by a decline in the pituitary glands ability to produce LH. The result is Andropause. Note, An injury or childhood disease such as *mumps can also impair the testicles’ ability to produce testosterone. *The latter is considered a medical condition called primary hypogonadism, and may qualify you to have your testosterone therapy paid for through your insurance carrier.

The good news - Symptoms can be easily corrected by replacing testosterone!

Testosterone Supplementation Therapy for Older Men: Potential Benefits and Risks.

Gruenewald DA, Matsumoto AM.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Division of Gerontology and Geriatric Medicine, Department of Medicine, and Population Center for Research in Reproduction, University of Washington School of Medicine, Seattle, Washington.

Serum testosterone levels decline gradually and progressively with aging in men. Many manifestations associated with aging in men, including muscle atrophy and weakness, osteoporosis, reduced sexual functioning, and increased fat mass, are similar to changes associated with testosterone deficiency in young men. These similarities suggest that testosterone supplementation may prevent or reverse the effects of aging.

A MEDLINE search was performed to identify studies of testosterone supplementation therapy in older men. A structured, qualitative review was performed of placebo-controlled trials that included men aged 60 and older and evaluated one or more physical, cognitive, affective, functional, or quality-of-life outcomes. Studies focusing on patients with severe systemic diseases and hormone deficiencies related to specific diseases were excluded. In healthy older men with low-normal to mildly decreased testosterone levels, testosterone supplementation increased lean body mass and decreased fat mass. Upper and lower body strength, functional performance, sexual functioning, and mood were improved or unchanged with testosterone replacement. Variable effects on cognitive function were reported, with improvements in some cognitive domains (e.g., spatial, working, and verbal memory). Testosterone supplementation improved exercise-induced coronary ischemia in men with coronary heart disease, whereas angina pectoris was improved or unchanged. In a few studies, men with low testosterone levels were more likely to experience improvements in lumbar bone mineral density, self-perceived functional status, libido, erectile function, and exercise-induced coronary ischemia with testosterone replacement than men with less marked testosterone deficiency. No major unfavorable effects on lipids were reported, but hematocrit and prostate specific antigen levels often increased. Based on these results, testosterone supplementation cannot be recommended at this time for older men with normal or low-normal testosterone levels and no clinical manifestations of hypogonadism. However, testosterone replacement may be warranted in older men with markedly decreased testosterone levels, regardless of symptoms, and in men with mildly decreased testosterone levels and symptoms or signs suggesting hypogonadism. The long-term safety and efficacy of testosterone supplementation remain uncertain. Establishment of evidence-based indications will depend on further demonstrations of favorable clinical outcomes and symptomatic, functional, and quality-of-life benefits in carefully performed, long-term, randomized, placebo-controlled clinical trials. J Am Geriatr Soc 51:101-115, 2003.

Expert Opin Pharmacother 2003 Feb;4(2):183-90

Andropause: an androgen deficiency state in the ageing male. Demers LM.

Distinguished Professor of Pathology and Medicine, Penn State University College of Medicine, The MS Hershey Medical Center, Hershey, PA 17033, USA. lmd4@psu.edu

An age-related decline in circulating testosterone levels has been shown to occur in the adult male population starting as early as middle age and continuing on into old age. This decline in testosterone has been associated with a number of changes in body composition and sexual performance in the male that are directly attributable to an androgen deficiency state, which can be restored by the use of testosterone replacement therapy. The term 'andropause' has been used to describe this gradual drop in testosterone in the ageing male and is characterized by different endocrine, somatic and psychic changes that become more pronounced as the male gets older. For some males, the adjustment of circulating testosterone levels with replacement therapy to levels seen in young men can improve physical performance, induce a sense of well-being and restore the androgen-dependent sex drive that declines with ageing.

J Clin Endocrinol Metab 2002 Nov;87(11):5001-7

Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men.

Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM.

Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

Circulating testosterone (T) levels have behavioral and neurological effects in both human and nonhuman species. Both T concentrations and neuropsychological function decrease substantially with age in men. The purpose of this prospective, longitudinal study was to investigate the relationships between age-associated decreases in endogenous serum T and free T concentrations and declines in neuropsychological performance. Participants were volunteers from the Baltimore Longitudinal Study of Aging, aged 50-91 yr at baseline T assessment. Four hundred seven men were followed for an average of 10 yr, with assessments of multiple cognitive domains and contemporaneous determination of serum total T, SHBG, and a free T index (FTI). We administered neuropsychological tests of verbal and visual memory, mental status, visuomotor scanning and attention, verbal knowledge/language, visuospatial ability, and depressive symptomatology. Higher FTI was associated with better scores on visual and verbal memory, visuospatial functioning, and visuomotor scanning and a reduced rate of longitudinal decline in visual memory. Men classified as hypogonadal had significantly lower scores on measures of memory and visuospatial performance and a faster rate of decline in visual memory. No relations between total T or the FTI and measures of verbal knowledge, mental status, or depressive symptoms were observed. These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men.


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